|
Symbol Name ID |
Ifih1
interferon induced with helicase C domain 1 MGI:1918836 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating antibody level |
Lymphocytosis |
Chronic lymphatic leukemia |
Generalized lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Hepatitis |
Increased circulating interferon-gamma concentration |
Increased circulating Interferon-alpha concentration |
Chilblains |
Atopic dermatitis |
Skin rash |
Myositis |
Panniculitis |
Pneumonia |
Autoimmunity |
Antiphospholipid antibody positivity |
Recurrent lower respiratory tract infections |
| Disease(s) Associated with IFIH1 | ||||||||||||||||||
| Aicardi-Goutieres syndrome |
| Mouse Phenotypes | increased granulocyte number |
abnormal leukocyte cell number |
increased dendritic cell number |
increased plasma cell number |
increased macrophage cell number |
increased IgA level |
increased IgG level |
increased IgM level |
increased immunoglobulin level |
abnormal T cell activation |
abnormal macrophage activation involved in immune response |
abnormal cytokine level |
abnormal chemokine level |
abnormal interferon level |
abnormal interleukin level |
abnormal dendritic cell physiology |
abnormal dendritic cell antigen presentation |
abnormal cytokine secretion |
decreased interferon-alpha secretion |
decreased interferon-beta secretion |
decreased interleukin-6 secretion |
autoimmune response |
increased susceptibility to systemic lupus erythematosus |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
chronic liver inflammation |
increased inflammatory response |
glomerulonephritis |
skin inflammation |
increased susceptibility to Picornaviridae infection |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Ifih1Rgsc422/Ifih1Rgsc422 | |||||||||||||||||||||||||||||||
| Ifih1tm1.1Cln/Ifih1tm1.1Cln | |||||||||||||||||||||||||||||||
| Ifih1tm1Aki/Ifih1tm1Aki | |||||||||||||||||||||||||||||||
| Ifih1Rgsc422/Ifih1+ | |||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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